Review



ythdf2 yth domain family 2  (Novus Biologicals)


Bioz Verified Symbol Novus Biologicals is a verified supplier
Bioz Manufacturer Symbol Novus Biologicals manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 92
      Buy from Supplier

    Structured Review

    Novus Biologicals ythdf2 yth domain family 2
    Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote <t>YTHDF2</t> binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01
    Ythdf2 Yth Domain Family 2, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ythdf2+yth+domain+family+2/pm39709463-103-34-53?v=Novus+Biologicals
    Average 92 stars, based on 1 article reviews
    ythdf2 yth domain family 2 - by Bioz Stars, 2026-08
    92/100 stars

    Images

    1) Product Images from "MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis."

    Article Title: MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis.

    Journal: Biology direct

    doi: 10.1186/s13062-024-00572-0

    Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote YTHDF2 binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01
    Figure Legend Snippet: Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote YTHDF2 binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01

    Techniques Used: Expressing, Modification, Binding Assay, Quantitative RT-PCR, Western Blot, Transfection, Control

    Fig. 9 MLL1 promotes RBM15 expression by increasing H3K4me3 on the RBM15 promoter; RBM15 upregulates TRIM72 mRNA m6A modification, pro motes the binding between YTHDF2 and TRIM72, and then degrades TRIM72 mRNA and inhibits TRIM72 expression, thereby reducing the ubiquitination degradation of ADAM9, stabilizing the expression of ADAM9, and eventually promoting ferroptosis of trophoblasts and aggravating PE
    Figure Legend Snippet: Fig. 9 MLL1 promotes RBM15 expression by increasing H3K4me3 on the RBM15 promoter; RBM15 upregulates TRIM72 mRNA m6A modification, pro motes the binding between YTHDF2 and TRIM72, and then degrades TRIM72 mRNA and inhibits TRIM72 expression, thereby reducing the ubiquitination degradation of ADAM9, stabilizing the expression of ADAM9, and eventually promoting ferroptosis of trophoblasts and aggravating PE

    Techniques Used: Expressing, Modification, Binding Assay, Ubiquitin Proteomics



    Similar Products

    sirna targeting yth-domain family member 2 (ythdf2)  (Ribobio co)
    90
    Ribobio co sirna targeting yth-domain family member 2 (ythdf2)
    Sirna Targeting Yth Domain Family Member 2 (Ythdf2), supplied by Ribobio co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ythdf2+yth+domain+family+2/pm40000487-59-12-24?v=Ribobio+co
    Average 90 stars, based on 1 article reviews
    sirna targeting yth-domain family member 2 (ythdf2) - by Bioz Stars, 2026-08
    90/100 stars
    		  Buy from Supplier
    yth domain family member 2  (Proteintech)
    96
    Proteintech yth domain family member 2
    Yth Domain Family Member 2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ythdf2+yth+domain+family+2/pm39952076-72-45-55?v=Proteintech
    Average 96 stars, based on 1 article reviews
    yth domain family member 2 - by Bioz Stars, 2026-08
    96/100 stars
    		  Buy from Supplier
    ythdf2 yth domain family 2  (Novus Biologicals)
    92
    Novus Biologicals ythdf2 yth domain family 2
    Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote <t>YTHDF2</t> binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01
    Ythdf2 Yth Domain Family 2, supplied by Novus Biologicals, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ythdf2+yth+domain+family+2/pm39709463-103-34-53?v=Novus+Biologicals
    Average 92 stars, based on 1 article reviews
    ythdf2 yth domain family 2 - by Bioz Stars, 2026-08
    92/100 stars
    		  Buy from Supplier
    anti yth domain family 2  (Cell Signaling Technology Inc)
    95
    Cell Signaling Technology Inc anti yth domain family 2
    Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote <t>YTHDF2</t> binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01
    Anti Yth Domain Family 2, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ythdf2+yth+domain+family+2/10__1096_slash_fj__202400664r-93-67-74?v=Cell+Signaling+Technology+Inc
    Average 95 stars, based on 1 article reviews
    anti yth domain family 2 - by Bioz Stars, 2026-08
    95/100 stars
    		  Buy from Supplier
    yth domain family protein-2 (ythdf2)-specific small interfering rnas (sirnas)  (Ribobio co)
    90
    Ribobio co yth domain family protein-2 (ythdf2)-specific small interfering rnas (sirnas)
    Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote <t>YTHDF2</t> binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01
    Yth Domain Family Protein 2 (Ythdf2) Specific Small Interfering Rnas (Sirnas), supplied by Ribobio co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ythdf2+yth+domain+family+2/pm36925202-43-5-12?v=Ribobio+co
    Average 90 stars, based on 1 article reviews
    yth domain family protein-2 (ythdf2)-specific small interfering rnas (sirnas) - by Bioz Stars, 2026-08
    90/100 stars
    		  Buy from Supplier
    antibodies against yth domain family protein 2  (Proteintech)
    96
    Proteintech antibodies against yth domain family protein 2
    Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote <t>YTHDF2</t> binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01
    Antibodies Against Yth Domain Family Protein 2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ythdf2+yth+domain+family+2/pm36084736-54-0-14?v=Proteintech
    Average 96 stars, based on 1 article reviews
    antibodies against yth domain family protein 2 - by Bioz Stars, 2026-08
    96/100 stars
    		  Buy from Supplier
    yth domain family 2  (Proteintech)
    96
    Proteintech yth domain family 2
    Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote <t>YTHDF2</t> binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01
    Yth Domain Family 2, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ythdf2+yth+domain+family+2/pmc07845411-98-15-21?v=Proteintech
    Average 96 stars, based on 1 article reviews
    yth domain family 2 - by Bioz Stars, 2026-08
    96/100 stars
    		  Buy from Supplier

    Image Search Results


    Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote YTHDF2 binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01

    Journal: Biology direct

    Article Title: MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis.

    doi: 10.1186/s13062-024-00572-0

    Figure Lengend Snippet: Fig. 3 MLL1 promotes RBM15 expression by increasing H3K4me3 modification; RBM15 enhances m6A modification to promote YTHDF2 binding to TRIM72 mRNA and degrade TRIM72, thereby inhibiting TRIM72 expression. A: Analysis of the enrichment of MLL1 and H3K4me3 on RBM15 promoter in tissues (n = 6) and cells (n = 3) by ChIP. B-C: Detection of RBM15 and TRIM72 expressions in tissues (n = 6) and cells (n = 3) by qRT-PCR and Western blot. D: Quantitative analysis of m6A modification in tissues (n = 6) and cells (n = 3). E: Analysis of the m6A modification on TRIM72 mRNA and the enrichment of YTHDF2 in tissues (n = 6) and cells (n = 3) by RIP. F: Detection of TRIM72 mRNA stability in cells (n = 3) by actinomycin D; HTR-8/SVneo cells were transfected with sh-YTHDF2, with sh-NC as the control. G-H: Detection of YTHDF2 expression in cells (n = 3) by qRT-PCR and Western blot. Data in panels AEF were analyzed by two-way ANOVA, and data in panels BCD were analyzed by one-way ANOVA, followed by Tukey’s multiple comparisons test. Data in panels GH were analyzed by t test. **P < 0.01

    Article Snippet: R: T G A T A A A A G C C C A G C C C A G T A C Note: MLL1: mixed-lineage leukemia 1; RBM15: RNA binding motif protein 15; YTHDF2: YTH domain family 2; TRIM72: tripartite motif containing 72; ADAM9: ADAM metallopeptidase domain 9; GAPDH: glyceraldehyde-3-phosphate dehydrogenase nb600-256, NOVUS) and H3K4me3 (1:1000, ab213224, Abcam) at 4 °C overnight.

    Techniques: Expressing, Modification, Binding Assay, Quantitative RT-PCR, Western Blot, Transfection, Control

    Fig. 9 MLL1 promotes RBM15 expression by increasing H3K4me3 on the RBM15 promoter; RBM15 upregulates TRIM72 mRNA m6A modification, pro motes the binding between YTHDF2 and TRIM72, and then degrades TRIM72 mRNA and inhibits TRIM72 expression, thereby reducing the ubiquitination degradation of ADAM9, stabilizing the expression of ADAM9, and eventually promoting ferroptosis of trophoblasts and aggravating PE

    Journal: Biology direct

    Article Title: MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis.

    doi: 10.1186/s13062-024-00572-0

    Figure Lengend Snippet: Fig. 9 MLL1 promotes RBM15 expression by increasing H3K4me3 on the RBM15 promoter; RBM15 upregulates TRIM72 mRNA m6A modification, pro motes the binding between YTHDF2 and TRIM72, and then degrades TRIM72 mRNA and inhibits TRIM72 expression, thereby reducing the ubiquitination degradation of ADAM9, stabilizing the expression of ADAM9, and eventually promoting ferroptosis of trophoblasts and aggravating PE

    Article Snippet: R: T G A T A A A A G C C C A G C C C A G T A C Note: MLL1: mixed-lineage leukemia 1; RBM15: RNA binding motif protein 15; YTHDF2: YTH domain family 2; TRIM72: tripartite motif containing 72; ADAM9: ADAM metallopeptidase domain 9; GAPDH: glyceraldehyde-3-phosphate dehydrogenase nb600-256, NOVUS) and H3K4me3 (1:1000, ab213224, Abcam) at 4 °C overnight.

    Techniques: Expressing, Modification, Binding Assay, Ubiquitin Proteomics